Platelet coagulant activities and hemostasis: a hypothesis.

Platelets have recently been shown to participate in reactions with blood coagulation factors at every stage of intrinsic clotting, from contact activation to fibrin formation. Platelets can trigger intrinsic coagulation by two alternative pathways, the first of which involves factors XII and Xl and adenosine diphosphate, and the second of which bypasses factor XII, provided factor Xl and collagen are present. Additional evidence indicates that subsequent coagulation reactions occur on the platelet surface, where active clotting factors are protected from inactivation by glimmer comes from Rollebon ‘s direction. Slow, lazy. sulky. the facts adapt themselves at a pinch to the order I wish to give them, but it remains outside of them. I have the impression of doing a work of pure imagination-Jean-Paul Sartre, La Naus#{233}e, 1938